Lunasin, Epigenetics and You!

TAKING CONTROL WITH LUNASIN

What is Lunasin? A naturally occurring peptide and originally identified in soy. This peptide consists of 43 amino acids.

How does it work? The lunasin peptide is the first compound identified to work at the epigenetic level to promote optimal health.

To learn more about lunasin and epigenetics view the video.

What if… there was a simple, proven way to turn good genes on, turn bad genes off and become your best possible you? To improve upon the genetic code your parents left you and even pass those healthy epigenetics on to your own kids?

Numerous independent studies demonstrate lunasin’s superior support for cancer-preventive effects, cardiovascular health, immune system support, significant anti-inflammatory properties, anti-aging, skin health, and more… Contact Us for information on other studies, protocols using lunasin, and health results.

LUNASIN and EPIGENETICS

The FIRST ingredient PROVEN to turn good genes on, and bad genes off.

Dr. Alfredo Galvez, Reliv’s Chief Scientific Officer and the discoverer of the lunasin peptide: “Here’s a visual representation of lunasin’s epigenetic mechanism of action and the health effects associated with the epigenetic biomarkers (histone modifications) modulated by lunasin.

1) Lunasin specifically binds to histone H3-Lysine14 and inhibits its acetylation by the PCAF histone acetylase enzyme. The acetylation of H3-Lysine14 has been shown to be the key epigenetic biomarker associated with cholesterol biosynthesis, chronic inflammation, cancer formation and atherosclerosis (heart disease formation).

2) Lunasin binds to histone H4-Lysine 8, causing conformational changes to promote histone H4-Lysine16 acetylation by histone acetylase enzymes. Loss of H4-Lysine16 acetylation is the common epigenetic hallmark of cancer. H4-Lysine 16 acetylation is the essential epigenetic biomarker associated with optimal expression of housekeeping genes, normal brain functions and the healthy metabolic communications between the nucleus and mitochondria.”

Every cell in your body contains DNA – half from your mom, half from your dad. That’s your genome, the genetic blueprint that makes you you.

So what makes different cells perform different functions? The answer lies in your epigenome, a higher level of complexity within the cell. The epigenome consists of DNA packaging material and works as a series of genetic switches. It determines cell function by signaling your genome which genes to turn on and off.

The epigenome also influences how well each cell functions. In the epigenome, the right lifestyle choices trigger healthy gene expression — the healthy genes get switched on, the unhealthy ones get switched off. Problem is, even when you know what you are supposed to do – eat right, exercise, reduce stress, etc. – life sometimes gets in the way! So while you can’t change your DNA blueprint, you can influence the way that DNA expresses itself.

Epigenetic Nutrition for a Lifetime of Wellness Using Lunasin

Research Studies

Epigenetic biomarker, H3K14ac, its associated histone acetyltransferase enzyme, KAT7/HBO1, and their involvement in aging and chronic disease development.

1) Review article
H3K14: A histone site closely related to diseases
https://pmc.ncbi.nlm.nih.gov/articles/PMC12374959/

2) Cellular Senescence (Cellular Aging)
A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence
https://www.science.org/doi/10.1126/scitranslmed.abd2655

3) Alzheimer’s disease and neuroinflammation
Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis
https://www.biorxiv.org/content/10.64898/2026.02.19.706884v1

4) Cardiovascular disease and inflammation
Increased acetylation of H3K14 in the genomic regions that encode trained immunity enzymes in lysophosphatidylcholine-activated human aortic endothelial cells – Novel qualification markers for chronic disease risk factors and conditional DAMPs
https://www.sciencedirect.com/science/article/pii/S2213231719303866

Kat7 contributes to ponatinib-induced hypertension by promoting endothelial senescence and inflammatory responses through activating NF-KappaB signaling pathway
https://journals.lww.com/jhypertension/fulltext/2025/05000/kat7_contributes_to_ponatinib_induced_hypertension.14.aspx

5) Breast Cancer
A chemical toolbox for the study of bromodomains and epigenetic signaling
https://www.nature.com/articles/s41467-019-09672-2

6) Colorectal Cancer
Targeting KAT7 inhibits the progression of colorectal cancer
https://www.thno.org/v15p1478.htm

7) Ovarian Cancer
HBO1 determines epithelial-mesenchymal transition and promotes immunotherapy resistance in ovarian cancer cells
https://link.springer.com/article/10.1007/s13402-025-01055-8

8) Leukemia
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements
https://www.nature.com/articles/s41375-020-1001-z

HBO1 is required for the maintenance of leukemia stem cells
https://www.nature.com/articles/s41586-019-1835-6

Histone acetylation by HBO1 (KAT7) activates Wnt/B-catenin signaling to promote leukemogenesis in B-cell acute lymphoblastic leukemia
https://www.nature.com/articles/s41419-023-06019-0

9) Prostate Cancer
BAZ2A-mediated repression via H3K14ac-marked enhancer promotes prostate cancer stem cells
https://link.springer.com/article/10.15252/embr.202153014

Reliv Lunasin Patents

Reliv is the only company with three U.S. patents on the combination of lunasin-enriched soy extract and Reliv Now®, covering measurable effects that include:

Lowering free fatty acid (FFA) levels, which improves insulin response, energy production, and appetite regulation.
Raising adiponectin, a hormone that enhances fat metabolism, insulin sensitivity, and cardiovascular health. High adiponectin levels in the blood are associated with reduced risk of Type 2 diabetes and weight loss.
Increasing leptin, the “satiety hormone” that regulates hunger, fat burning, and inflammation.

These outcomes support healthier metabolism and sustainable weight management – without relying on stimulants or appetite suppressants. Reliv’s patents prove that our formula works at the cellular level.

Reliv also proudly holds three additional lunasin-related patents:

Two patents on lunasin’s mechanism of action to reduce LDL cholesterol by targeting cholesterol production in the liver.
One composition-of-matter patent on our proprietary LunaRich^® technology, which delivers superior concentrations of bioactive lunasin.

Health Benefits

The Facts:

LunaRich® from Reliv optimizes bioactive lunasin more than any other source available today.
1997-2012: Fifteen Years of Research on Peptide Lunasin
Recognized by the American Heart Association! Circulation
With more than 80 published studies across 30+ research institutions, lunasin is one of the most scientifically supported ingredients in nutrition today – and only Reliv offers it at this level of quality and efficacy.

Lunasin / LunaRich Products

LunaRich elevates Reliv to a unique status in the nutrition industry. Reliv now owns an ingredient in its entirety, from the extraction process to the patented mechanisms of action within the body. And LunaRich isn’t just any ingredient; it’s the world’s first epigenetic superfood.

Reliv has always endeavored to remain on the cutting edge of nutrition science in formulating products. With the acquisition of lunasin, Reliv is now leading the industry in the budding field of nutritional epigenetics. New research shows that through nutrition people can influence which genes are expressed. Reliv is committed to building on this emerging science and developing nutritional solutions with lunasin and other plant-based nutrients that help people take control of their health.

Our exclusive LunaRich® line of products optimizes lunasin content like no other nutritional ingredient available today. We are here for guidance and support and have been doing that globally for almost two decades as an Independent Reliv Distributor.